Reincarnation of the Analytical Ultracentrifuge: Emerging Opportunities for Nanomedicine
Olenka Jibaja Valderrama, Ivo Nischang
Abstract
The analytical ultracentrifuge (AUC) and the modern field of analytical ultracentrifugation found its inception approximately a century ago. We highlight the scope of its major experimental opportunities as a transport-based method, contemporary and up-and-coming investigation potential for polymers, polymer-drug conjugates, polymer assemblies, as well as medical nanoparticles. Special focus lies on molar mass estimates of unimeric polymeric species, self-assemblies in solution, and (co)localization of multicomponent systems in solution alongside the material-biofluid interactions. We close with present challenges and incentives for future research.
Topics & Concepts
ChemistryNanomedicineUltracentrifugeNanotechnologyScope (computer science)PolymerMolar massIncentiveAnalytical UltracentrifugationAttritionNanoparticleChromatographyOrganic chemistryComputer scienceDentistryMaterials scienceMicroeconomicsEconomicsProgramming languageMedicineProtein purification and stabilityNanoparticle-Based Drug DeliveryMicrofluidic and Bio-sensing Technologies