Dual degradation mechanism of GPX4 degrader in induction of ferroptosis exerting anti-resistant tumor effect
Chao Wang, Cangxin Zheng, Han Wang, Sufang Shui, Hongwei Jin, Guoquan Liu, Fengrong Xu, Zhenming Liu, Liangren Zhang, Dan Sun, Ping Xu
Topics & Concepts
AutophagyGPX4ChemistryProteasomeLysosomeCell biologyUbiquitinDownregulation and upregulationCancer cellProteasome inhibitorBortezomibBiochemistryCancer researchCancerGlutathioneBiologyImmunologyApoptosisGlutathione peroxidaseGeneEnzymeGeneticsMultiple myelomaPeptidase Inhibition and AnalysisProtein Degradation and InhibitorsMultiple Myeloma Research and Treatments