Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer’s disease
Nanaka Kaneshiro, Masato Komai, Ryosuke Imaoka, Atsuya Ikeda, Yuji Kamikubo, Takashi Saito, Takaomi C. Saido, Taisuke Tomita, Tadafumi Hashimoto, Takeshi Iwatsubo, Takashi Sakurai, Takashi Uehara, Nobumasa Takasugi
Abstract
model mice. Furthermore, the T-RAP peptide derived from the βCTF binding site of TMEM30A improved endosomal anomalies, which could be a result of the restored lipid flippase activity. Our results provide insights into the mechanisms of vesicular traffic impairment and suggest a therapeutic target for AD.
Topics & Concepts
FlippaseEndosomeDiseaseAlzheimer's diseaseNeuroscienceChemistryCell biologyNanotechnologyComputational biologyMedicineBiologyBiochemistryPhosphatidylserineMembraneInternal medicineMaterials sciencePhospholipidIntracellularAlzheimer's disease research and treatmentsLipid Membrane Structure and BehaviorCellular transport and secretion