Akt inhibition-dependent downregulation of the Wnt/β-Catenin Signaling pathway contributes to antimony-induced neurotoxicity
Weiwei Shi, Yanfen Tang, Ye Zhi, Z. Li, Shali Yu, Junkang Jiang, Jinfeng Zhu, Jinlong Li, Feng Wang, Liling Su, Xinyuan Zhao
Topics & Concepts
Protein kinase BGSK-3NeurotoxicityWnt signaling pathwayGlycogen synthaseGSK3BChemistryPhosphorylationSignal transductionPI3K/AKT/mTOR pathwayCell biologyApoptosisCateninDownregulation and upregulationCancer researchBiologyBiochemistryToxicityOrganic chemistryGeneAluminum toxicity and tolerance in plants and animalsHeavy Metal Exposure and ToxicityArsenic contamination and mitigation