Exosomes derived from GDNF-modified human adipose mesenchymal stem cells ameliorate peritubular capillary loss in tubulointerstitial fibrosis by activating the SIRT1/eNOS signaling pathway
Lu Chen, Yanping Wang, Shulin Li, Bangjie Zuo, Xiangyu Zhang, Fengzhen Wang, Dong Sun
Abstract
Our study unveiled a mechanism by which exosomes ameliorate renal fibrosis: GDNF-AMSC-exos may activate an angiogenesis program in surviving PTCs after injury by activating the SIRT1/eNOS signaling pathway.
Topics & Concepts
Glial cell line-derived neurotrophic factorParacrine signallingMesenchymal stem cellExosomeCancer researchCell biologyNeurotrophic factorsFibrosisMicrovesiclesChemistryBiologyMedicinePathologyInternal medicineBiochemistrymicroRNAReceptorGeneExtracellular vesicles in diseaseCardiovascular Disease and AdiposityThermal Regulation in Medicine