Activation of perfluoroalkyl iodides by anions: extending the scope of halogen bond activation to C(sp<sup>3</sup>)–H amidation, C(sp<sup>2</sup>)–H iodination, and perfluoroalkylation reactions
Yaxin Wang, Zehui Cao, Qin He, Xin Huang, Jiaxi Liu, Helfried Neumann, Gong Chen, Matthias Beller
Abstract
A simple activation of perfluoroalkyl iodides by t BuONa or KOH allows the promotion of α-sp 3 C–H amidation reactions of alkyl ethers and benzylic hydrocarbons, C–H iodination of heteroaryl compounds, and perfluoroalkylations of electron-rich π bonds.
Topics & Concepts
ChemistryHomolysisHalogenationHalogenCatalysisAlkylMedicinal chemistryOrganic chemistryCombinatorial chemistryRadicalFluorine in Organic ChemistryPorphyrin and Phthalocyanine ChemistryCatalytic C–H Functionalization Methods