Delivery strategies in treatments of leukemia
Tianyuan Ci, Wentao Zhang, Yingyu Qiao, Huangjuan Li, Jing Zang, Hongjun Li, Nianping Feng, Zhen Gu
Abstract
pharmacokinetics of drugs, navigating the therapeutics to target cells or the tumor microenvironment and reversing drug resistance, which maximizes tumor elimination and alleviates systematic adverse effects. This review discusses available FDA-approved anti-leukemia drugs and therapies with a focus on the advances in the development of anti-leukemia drug delivery systems. Additionally, challenges in clinical translation of the delivery strategies and future research opportunities in leukemia treatment are also included.
Topics & Concepts
MedicineLeukemiaDrug deliveryPharmacologyPharmacokineticsImmunotherapyAdverse effectChemotherapyMalignancyDrugOncologyCancer researchInternal medicineImmunologyImmune systemChemistryOrganic chemistryCAR-T cell therapy researchAcute Myeloid Leukemia ResearchAcute Lymphoblastic Leukemia research