A MAPS Vaccine Induces Multipronged Systemic and Tissue-Resident Cellular Responses and Protects Mice against Mycobacterium tuberculosis
Joanne M. O’Hara, Shoko Wakabayashi, Noman Siddiqi, Elaine Cheung, Gregory H. Babunovic, Claudette M. Thompson, Ying‐Jie Lu, Eric J. Rubin, Richard Malley, Fan Zhang
Abstract
T cells. When tested in a mouse aerosol infection model, this vaccine significantly reduced bacterial loads in the lungs and spleens to the same extent as BCG. When used in conjunction with BCG, TB-MAPS further enhanced BCG-mediated protection, especially in the lungs, further supporting this construct as a promising TB vaccine candidate.
Topics & Concepts
Mycobacterium tuberculosisTuberculosisImmune systemCytotoxic T cellImmunologyCD8MedicineBiologyVirologyMicrobiologyPathologyIn vitroBiochemistryTuberculosis Research and Epidemiologyvaccines and immunoinformatics approachesMycobacterium research and diagnosis