Targeting tumor cell-to-macrophage communication by blocking Vtn-C1qbp interaction inhibits tumor progression via enhancing macrophage phagocytosis
Chen Zhang, Yi Liu, Jiayu Jiang, Chong Chen, Zhaojun Duan, Huifang Su, Shijian Wang, Baorui Tian, Yijun Shi, Rong Xiang, Yunping Luo
Abstract
This work has revealed that the Vtn-C1qbp axis is a new anti-phagocytic signal in tumors, and targeting Vtn and its interaction with C1qbp may sensitize cancer to immunotherapy, providing a new molecular target for the treatment of triple-negative breast cancer.
Topics & Concepts
PhagocytosisMacrophageBlocking (statistics)Cancer researchCell biologyChemistryTumor cellsBiologyIn vitroComputer scienceBiochemistryComputer networkPhagocytosis and Immune RegulationAdenosine and Purinergic SignalingErythrocyte Function and Pathophysiology