Remdesivir Resistance in Transplant Recipients With Persistent Coronavirus Disease 2019
John I Hogan, Ralf Duerr, Dacia Dimartino, Christian Marier, Sarah Hochman, Sameer Mehta, Guiqing Wang, Adriana Heguy
Abstract
New mutations conferring resistance to SARS-CoV-2 therapeutics have important clinical implications. We describe the first cases of an independently acquired V792I RNA-dependent RNA polymerase mutation developing in renal transplant recipients after remdesivir exposure. Our work underscores the need for augmented efforts to identify concerning mutations and address their clinical implications.
Topics & Concepts
MedicineCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakVirologyBetacoronavirusCoronavirusPandemicIntensive care medicineImmunologyDiseaseInfectious disease (medical specialty)Internal medicineOutbreakSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesInfectious Encephalopathies and Encephalitis