Carbonyl umpolung as an organometallic reagent surrogate
Xi‐Jie Dai, Chenchen Li, Chen-Chen Li, Chao-Jun Li, Chao-Jun Li
Abstract
, as organometallic reagent surrogates. This Tutorial Review describes the chronological development of this concept in our research group, detailing its creation in the context of a deoxygenation reaction and evolution to a more general carbon-carbon bond-forming strategy. The latter is demonstrated by the employment of carbonyl-derived alkyl carbanions in various transition-metal catalyzed chemical transformations, including 1,2-carbonyl/imine addition, conjugate addition, carboxylation, olefination, cross-coupling, allylation, alkylation and hydroalkylation.
Topics & Concepts
UmpolungReagentChemistryGroup 2 organometallic chemistryOrganometallic chemistryOrganic chemistryCombinatorial chemistryCatalysisMoleculeNucleophileCoordination Chemistry and OrganometallicsAsymmetric Synthesis and CatalysisAsymmetric Hydrogenation and Catalysis