Synthesis of C<sub>3</sub>-alkylated benzofurans <i>via</i> palladium-catalyzed regiocontrolled hydro-furanization of unactivated alkenes
Chi‐Fan Zhu, Cong‐Hui Gao, Wen‐Juan Hao, Yi‐Long Zhu, Shu‐Jiang Tu, De‐Cai Wang, Bo Jiang
Abstract
A new chelation-controlled hydrofuranization of unactivated olefins with α-alkynyl arylols is reported for the first time, and used to produce a wide range of C<sub>3</sub>-alkylated benzofurans with generally good yields under mild conditions.
Topics & Concepts
ChemistryAlkylationPalladiumCatalysisChelationOrganic chemistryCombinatorial chemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsSulfur-Based Synthesis Techniques