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DNA damage response inhibitors in cancer therapy: lessons from the past, current status and future implications

Yvette Drew, Frank T. Zenke, Nicola J. Curtin

2024Nature Reviews Drug Discovery145 citationsDOI

Topics & Concepts

DNA damageGenome instabilityDNA repairPARP inhibitorHomologous recombinationCancer researchPoly ADP ribose polymeraseClinical trialSynthetic lethalityCancerBiologyMedicineBioinformaticsComputational biologyDNAGeneticsPolymerasePARP inhibition in cancer therapyDNA Repair MechanismsCRISPR and Genetic Engineering
DNA damage response inhibitors in cancer therapy: lessons from the past, current status and future implications | Litcius