Indolizine synthesis <i>via</i> copper-catalyzed cyclization of <i>gem</i>-difluoroalkenes and 2-(pyridin-2-yl)acetate derivatives
Chuan‐Jun Lu, Xin Yu, Yuting Chen, Qingbao Song, Hong Wang
Abstract
A novel and versatile approach to construct substituted indolizines through copper-catalyzed coupling cyclization of 2-(pyridin-2-yl)acetate with <italic>gem</italic>-difluoroalkenes has been developed.
Topics & Concepts
ChemistryIndolizineCatalysisCopperMedicinal chemistryCombinatorial chemistryOrganic chemistrySynthesis and Reactivity of HeterocyclesCyclopropane Reaction MechanismsCatalytic C–H Functionalization Methods