Human sirtuins are differentially sensitive to inhibition by nitrosating agents and other cysteine oxidants
Kelsey Kalous, Sarah L. Wynia‐Smith, Steven B. Summers, Brian C. Smith
Abstract
-nitrosation. Surprisingly, the mitochondrial sirtuins Sirt3 and Sirt5 were resistant to inhibition by cysteine oxidants. Collectively, these results suggest that nitric oxide-derived oxidants may causatively link nuclear and cytosolic sirtuin inhibition to aging-related inflammatory disease development.
Topics & Concepts
SirtuinSIRT2SIRT3CysteineBiochemistryNAD+ kinaseNitric oxideChemistryGlutathioneNitrosationOxidative phosphorylationOxidative stressPeroxynitriteS-NitrosylationCytosolEnzymeSuperoxideOrganic chemistrySirtuins and Resveratrol in MedicineAutophagy in Disease and TherapyAdipose Tissue and Metabolism