Titanium-nanostructured and PEGylated Doxorubicin Diminish Chemotherapeutic Resistance in 3-Methylcholanthrene Renal Epithelial Cell Carcinoma via KRAS/FKBP5/P53/JAK2 Signaling
Mai O. Kadry, Rehab M. Abdel‐Megeed
Abstract
Nanoparticle (NP) drug delivery systems have been developed recently to resolve the obstacle of drug resistance, contributing to the effective drug delivery to the target organ. A comparative study was carried out herein between doxorubicin (DOX), doxorubicin-loaded titanium NPs, DOX-loaded lactoferrin NPs, DOX-NPs, and PEGylated-doxorubicin (PEG-DOX) on the reno-carcinogenic impact of 3-methylcholanthrene (CA).
Topics & Concepts
DoxorubicinChemistryDrug deliveryPharmacologyCancer researchMedicineChemotherapyInternal medicineOrganic chemistryMicroRNA in disease regulationFerroptosis and cancer prognosisRenal cell carcinoma treatment