Beyond the approved: target sites and inhibitors of bacterial RNA polymerase from bacteria and fungi
Susanne H. Kirsch, F. P. Jake Haeckl, Rolf Müller
Abstract
develop resistance, not only against Rif and other RNAP inhibitors. To overcome this problem, novel RNAP inhibitors exhibiting different target sites are urgently needed. This review includes recent developments published between 2016 and today. Particular focus is placed on novel findings concerning already known bacterial RNAP inhibitors, the characterization and development of new compounds isolated from bacteria and fungi, and providing brief insights into promising new synthetic compounds.
Topics & Concepts
RifamycinRNA polymeraseBiologyBacteriaMycobacterium tuberculosisMicrobiologyNatural productPolymeraseRifampicinAntibioticsEnzymeComputational biologyTuberculosisGeneRNAGeneticsBiochemistryMedicinePathologyMicrobial Natural Products and BiosynthesisMycobacterium research and diagnosisAntibiotic Resistance in Bacteria