Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein
Enyong Dai, Leng Han, Jiao Liu, Yangchun Xie, Guido Kroemer, Daniel J. Klionsky, Herbert J. Zeh, Rui Kang, Jing Wang, Daolin Tang
Abstract
DAMP, damage-associated molecular pattern; PBMCMs, peripheral blood mononuclear cell-derived macrophages; PDAC, pancreatic ductal adenocarcinoma; s.c., subcutaneously; TAMs, tumor-associated macrophages; TME, tumor microenvironment.
Topics & Concepts
KRASBiologyAutophagyCancer researchMacrophage polarizationOncogeneExtracellularMutationImmune systemCancerCell biologyMacrophageGeneticsGeneApoptosisIn vitroCell cycleFerroptosis and cancer prognosisExtracellular vesicles in diseaseAutophagy in Disease and Therapy