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Metabolic activation of drugs by cytochrome P450 enzymes: Biochemical insights into mechanism-based inactivation by fibroblast growth factor receptor inhibitors and chemical approaches to attenuate reactive metabolite formation

Lloyd Wei Tat Tang, Eric Chun Yong Chan

2022Biochemical Pharmacology12 citationsDOI

Topics & Concepts

Cytochrome P450Mechanism (biology)Metabolic pathwayMetaboliteDrug discoveryChemistryEnzymeDrugBiochemistryDrug metabolismPharmacologyBiologyPhilosophyEpistemologyPharmacogenetics and Drug MetabolismLung Cancer Treatments and MutationsFibroblast Growth Factor Research
Metabolic activation of drugs by cytochrome P450 enzymes: Biochemical insights into mechanism-based inactivation by fibroblast growth factor receptor inhibitors and chemical approaches to attenuate reactive metabolite formation | Litcius