Non-alkylator anti-glioblastoma agents induced cell cycle G2/M arrest and apoptosis: Design, in silico physicochemical and SAR studies of 2-aminoquinoline-3-carboxamides
Pengtao Yuan, Xiangyu Gu, Xintong Ni, Yingxue Qi, Xusheng Shao, Xiaoyong Xu, Jianwen Liu, Xuhong Qian
Topics & Concepts
ChemistryIn silicoCell cycle checkpointApoptosisCell cycleCytotoxicityGlioblastomaCell cultureCisplatinFlow cytometryCancer researchIn vitroGliomaCellPharmacologyChemotherapyBiochemistryImmunologyInternal medicineBiologyMedicineGeneticsGeneCancer therapeutics and mechanismsComputational Drug Discovery MethodsGlioma Diagnosis and Treatment