Localized pmrB hypermutation drives the evolution of colistin heteroresistance
Natalia Kapel, Julio Diaz Caballero, R. Craig MacLean
Abstract
per cell division). PmrAB provides resistance to antimicrobial peptides that are involved in host immunity, suggesting that this pathogen may have evolved a highly mutable pmrB as an adaptation to host immunity.
Topics & Concepts
ColistinBiologySomatic hypermutationMicrobiologyDrug resistanceNeisseria meningitidisPathogenPseudomonas aeruginosaAntibioticsVirologyGeneticsBacteriaAntibodyB cellAntibiotic Resistance in BacteriaBacterial Genetics and BiotechnologyEvolution and Genetic Dynamics