A class of water-soluble Fe(<scp>iii</scp>) coordination complexes as <i>T</i><sub>1</sub>-weighted MRI contrast agents
Run Wang, Lu An, HE Jing, Mengmeng Li, Jingjing Jiao, Shiping Yang
Abstract
Iron-based coordination complexes are showing increasing potential to be alternatives for T1-weighted magnetic resonance imaging (MRI) and contribute to the safety of gadolinium-based compounds. In this work, three water-soluble iron-based complexes constructed using catechol ligands exhibiting T1-weighted MRI contrast behavior are described. The longitudinal relaxivity (r1) increase from 0.88 to 1.43 mM-1 s-1 mainly depends on the sizes and the number of water molecules in the second and outer spheres around the discrete complexes.
Topics & Concepts
Contrast (vision)Magnetic resonance imagingWater solubleClass (philosophy)Nuclear magnetic resonanceIn vivoMaterials scienceCrystallographyChemistryPhysicsComputer scienceMedicineOrganic chemistryRadiologyOpticsBiologyBiotechnologyArtificial intelligenceLanthanide and Transition Metal ComplexesMagnetism in coordination complexesMetal-Organic Frameworks: Synthesis and Applications