Backbone-enabled modification of peptides with benzoquinone <i>via</i> palladium-catalyzed δ-C(sp<sup>2</sup>)–H functionalization
Fengjie Lu, Yi Sun, Yaning Liu, Yujie Geng, Ensheng Zhang, Jian Tang
Abstract
)-H functionalization has been achieved. The amide groups of peptides serve as internal directional groups, facilitating C-H functionalization through a kinetically less favored six-membered palladacycle. This methodology presents novel opportunities for the late-stage site-selective diversification of peptides.
Topics & Concepts
Surface modificationPalladiumChemistryCatalysisBenzoquinoneCombinatorial chemistryPeptideStereochemistryOrganic chemistryBiochemistryPhysical chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsChemical Synthesis and Analysis