Anti–USAG-1 therapy for tooth regeneration through enhanced BMP signaling
Akiko Murashima-Suginami, Honoka Kiso, Yoshihito Tokita, Emiko Mihara, Yukiko Nambu, Ryuji Uozumi, Yasuhiko Tabata, Kazuhisa Bessho, Junichi Takagi, Manabu Sugai, Katsu Takahashi
Abstract
controls the number of teeth by inhibiting development of potential tooth germs in wild-type or mutant mice missing teeth. Anti-USAG-1 antibody administration is, therefore, a promising approach for tooth regeneration therapy.
Topics & Concepts
Regeneration (biology)DentistryBone morphogenetic protein 2Signal transductionCell biologyMedicineBiologyBiochemistryIn vitrodental development and anomaliesOral and Maxillofacial PathologyOral and gingival health research