Human Brain Organoids: Development and Applications
Wu Hongxi, Wang Ruting, Liu Yiyang, Huang Qinglian, Chen Jibing, Feng Jiang
Abstract
Cortical brain organoidTo simulate human brain development, study neurodevelopment and disease mechanisms, create disease models, and conduct drug screening and toxicity tests.May increase heterogeneity, have lower maturity and complexity than real brains, and require high technical expertise.
Topics & Concepts
OrganoidHuman brainEmbryonic stem cellNeuroscienceBiologyInduced pluripotent stem cellBrain developmentMicrogliaCell typeCellGeneImmunologyGeneticsInflammationPluripotent Stem Cells Research3D Printing in Biomedical ResearchNeurogenesis and neuroplasticity mechanisms