Risk Factors for Coronavirus Disease 2019 (COVID-19)-Associated Pulmonary Aspergillosis in Critically Ill Patients: A Nationwide, Multicenter, Retrospective Cohort Study
Si‐Ho Kim, Jin Yeong Hong, Seongman Bae, Ho‐Jin Lee, Yu Mi Wi, Jae‐Hoon Ko, Bomi Kim, Eun‐Jeong Joo, Hyeri Seok, Hye Jin Shi, Jeong Rae Yoo, Miri Hyun, Hyun Ah Kim, Sukbin Jang, Seok Jun Mun, Jungok Kim, Min‐Chul Kim, Dong Sik Jung, Sung‐Han Kim, Kyong Ran Peck
Abstract
BACKGROUND: Coronavirus disease 2019 (COVID-19) is often accompanied by secondary infections, such as invasive aspergillosis. In this study, risk factors for developing COVID-19-associated pulmonary aspergillosis (CAPA) and their clinical outcomes were evaluated. METHODS: This multicenter retrospective cohort study included critically ill COVID-19 patients from July 2020 through March 2021. Critically ill patients were defined as patients requiring high-flow respiratory support or mechanical ventilation. CAPA was defined based on the 2020 European Confederation of Medical Mycology and the International Society for Human and Animal Mycology consensus criteria. Factors associated with CAPA were analyzed, and their clinical outcomes were adjusted by a propensity score-matched model. RESULTS: = 0.089). CONCLUSION: Our study showed that the dose of corticosteroid use might be a risk factor for CAPA development and the possibility of CAPA contributing to adverse outcomes in critically ill COVID-19 patients.