Catalyst-Free Annulation of Acylethynylpyrroles with 1-Pyrrolines: A Straightforward Access to Tetrahydrodipyrrolo[1,2-<i>a</i>:1′,2′-<i>c</i>]imidazoles
Ludmila A. Oparina, Kseniya V. Belyaeva, Nikita A. Kolyvanov, Igor А. Ushakov, Maxim D. Gotsko, Lyubov N. Sobenina, Alexander V. Vashchenko, Б. А. Трофимов
Abstract
Acylethynylpyrroles undergo facile (rt, MeCN or MeOH, 24–72 h) catalyst-free annulation with 1-pyrrolines to afford acylmethylenetetrahydrodipyrrolo[1,2-a:1′,2′-c]imidazoles in up to 93% yield and 90% E-stereoselectivity of the olefin moiety.
Topics & Concepts
AnnulationCatalysisChemistryCombinatorial chemistryOrganic chemistrySynthesis and Characterization of PyrrolesAsymmetric Synthesis and CatalysisOxidative Organic Chemistry Reactions