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2-Thiopyrimidine/chalcone hybrids: design, synthesis, ADMET prediction, and anticancer evaluation as STAT3/STAT5a inhibitors

Phoebe F. Lamie, John N. Philoppes

2020Journal of Enzyme Inhibition and Medicinal Chemistry34 citationsDOIOpen Access PDF

Abstract

=113.31 and 50.75 µM, against STAT3 and STAT5a, respectively). Prediction of physicochemical properties, drug likeness score, pharmacokinetic and toxic properties was detected.

Topics & Concepts

ChalconeChemistryIC50CytotoxicityCytotoxic T cellCell culturePharmacologyStereochemistryBiochemistryIn vitroBiologyGeneticsSynthesis and biological activityCytokine Signaling Pathways and InteractionsQuinazolinone synthesis and applications
2-Thiopyrimidine/chalcone hybrids: design, synthesis, ADMET prediction, and anticancer evaluation as STAT3/STAT5a inhibitors | Litcius