Drug‐Induced Liver Injury in GI Practice
Naemat Sandhu, Victor J. Navarro
Abstract
Although drug-induced liver injury (DILI) is a rare clinical event, it carries significant morbidity and mortality, leaving it as the leading cause of acute liver failure in the United States. It is one of the most challenging diagnoses encountered by gastroenterologists. The development of various drug injury networks has played a vital role in expanding our knowledge regarding drug-related and herbal and dietary supplement-related liver injury. In this review, we discuss what defines liver injury, epidemiology of DILI, its biochemical and pathologic patterns, and management.
Topics & Concepts
Liver injuryMedicineDrugIntensive care medicineEpidemiologyDrug developmentPharmacologyInternal medicineDrug-Induced Hepatotoxicity and ProtectionPharmacogenetics and Drug MetabolismChemotherapy-induced organ toxicity mitigation