Efficient photosensitizers with aggregation-induced emission characteristics for lysosome- and Gram-positive bacteria-targeted photodynamic therapy
Jiabao Zhuang, Hanxiao Yang, Yue Li, Bing Wang, Nan Li, Na Zhao
Abstract
Two efficient photosensitizers (PSs) with aggregation-induced emission characteristics were designed and synthesized for specific lysosome-targeted photodynamic therapy (PDT). Both PSs efficiently discriminated Gram-positive bacteria from Gram-negative bacteria and killed Gram-positive bacteria through the PDT effect.
Topics & Concepts
Photodynamic therapyLysosomeAggregation-induced emissionGramBacteriaChemistryGram-positive bacteriaGram-negative bacteriaNanotechnologyCombinatorial chemistryMaterials scienceBiochemistryBiologyOrganic chemistryEscherichia coliFluorescenceAntibioticsGeneticsGenePhysicsQuantum mechanicsEnzymePhotodynamic Therapy Research StudiesNanoplatforms for cancer theranosticsLuminescence and Fluorescent Materials