Molecular Basis of the Versatile Regulatory Mechanism of HtrA-Type Protease AlgW from Pseudomonas aeruginosa
Tao Li, Yingjie Song, Liming Luo, Ninglin Zhao, Lihui He, Mei Kang, Changcheng Li, Yibo Zhu, Yalin Shen, Chang Zhao, Jing Yang, Qin Huang, Xingyu Mou, Zhiyong Zong, Jinliang Yang, Hong Tang, Yong‐Xing He, Rui Bao
Abstract
HtrA-family proteases are commonly employed to sense the protein folding stress and activate the regulated intramembrane proteolysis (RIP) cascade in Gram-negative bacteria. Here, we reveal the unique dual-signal activation and dynamic regulation properties of AlgW, an HtrA-type protease triggering the AlgU stress-response pathway, which controls alginate production and mucoid conversion in Pseudomonas aeruginosa .
Topics & Concepts
Periplasmic spaceProteaseProteolysisPDZ domainProteasesSerine proteaseCell biologyBacterial outer membraneBiochemistryChemistryBiologyEscherichia coliEnzymeGeneVibrio bacteria research studiesBacterial Genetics and BiotechnologyBacterial biofilms and quorum sensing