A cellular and spatial atlas of TP53-associated tissue remodeling defines a multicellular tumor ecosystem in lung adenocarcinoma
William Zhao, Thinh T. Nguyen, Atharva Bhagwat, Akhil Kumar, Bruno Giotti, Benjamin Kepecs, Jason L. Weirather, Navin R. Mahadevan, Åsa Segerstolpe, Komal Dolasia, Jamshid Abdul‐Ghafar, N. Besson, Stephanie M. Jones, Brian Y. Soong, Chendi Li, Sébastien Vigneau, Michal Slyper, Isaac Wakiro, Mei-Ju Su, Karla Helvie, Allison Frangieh, Judit Jané‐Valbuena, Orr Ashenberg, Mark Awad, Asaf Rotem, Raphael Bueno, Orit Rozenblatt–Rosen, Kathleen L. Pfaff, Scott J. Rodig, Aaron N. Hata, Aviv Regev, Bruce E. Johnson, Alexander M. Tsankov
Topics & Concepts
BiologyMulticellular organismAdenocarcinomaCancer researchTranscriptomeTumor microenvironmentLungDownregulation and upregulationImmune systemGeneLung cancerGene expressionImmunohistochemistryHuman Protein AtlasGene expression profilingImmune checkpointRegulation of gene expressionBlockadeImmunotherapyCellCell cultureCancerAtlas (anatomy)PathologyTumor progressionExtracellular matrixAdenocarcinoma of the lungHuman lungCancer Genomics and DiagnosticsRadiomics and Machine Learning in Medical ImagingFerroptosis and cancer prognosis