Polymorphic USP8 allele promotes Parkinson’s disease by inducing the accumulation of α-synuclein through deubiquitination
Shouhai Wu, Tongxiang Lin, Yang Xu
Topics & Concepts
BiologyAlleleDopaminergicInduced pluripotent stem cellEmbryonic stem cellPhenotypeParkinson's diseaseGeneticsPathogenesisGeneCell biologyDiseaseDopamineNeuroscienceImmunologyMedicinePathologyGenetics and Neurodevelopmental DisordersUbiquitin and proteasome pathwaysNuclear Receptors and Signaling