Cross-Comparison of Human iPSC Motor Neuron Models of Familial and Sporadic ALS Reveals Early and Convergent Transcriptomic Disease Signatures
Ritchie Ho, Michael J. Workman, Pranav Mathkar, Kathryn Wu, Kevin J. Kim, Jacqueline G. O’Rourke, M Kellogg, Valérie Montel, Maria G. Bañuelos, Olubankole Aladesuyi Arogundade, Sandra Díaz-García, Daniel Oheb, Steven K. Huang, Irina Khrebtukova, Lisa Watson, John Ravits, Kevin Taylor, Robert H. Baloh, Clive N. Svendsen
Topics & Concepts
BiologyAmyotrophic lateral sclerosisInduced pluripotent stem cellHox geneTranscriptomePhenotypeGeneticsComputational biologyDiseaseMotor neuronGeneNeuroscienceGene expressionEmbryonic stem cellPathologyMedicineSpinal cordAmyotrophic Lateral Sclerosis ResearchPluripotent Stem Cells ResearchSingle-cell and spatial transcriptomics