Mus musculus Papillomavirus 1: a New Frontier in Animal Models of Papillomavirus Pathogenesis
Megan E. Spurgeon, Paul F. Lambert
Abstract
Animal models of viral pathogenesis are essential tools in human disease research. Human papillomaviruses (HPVs) are a significant public health issue due to their widespread sexual transmission and oncogenic potential. Infection-based models of papillomavirus pathogenesis have been complicated by their strict species and tissue specificity. In this Gem, we discuss the discovery of a murine papillomavirus, Mus musculus papillomavirus 1 (MmuPV1), and how its experimental use represents a major advancement in models of papillomavirus-induced pathogenesis/carcinogenesis, and their transmission.
Topics & Concepts
BiologyPathogenesisHuman papillomavirusBovine papillomavirusVirologyTransmission (telecommunications)CarcinogenesisPapillomaviridaeAnimal modelSexual transmissionGeneticsImmunologyCancerCervical cancerGeneGenomeMedicineElectrical engineeringInternal medicineMicrobicideHuman immunodeficiency virus (HIV)EngineeringEndocrinologyCervical Cancer and HPV ResearchCancer-related Molecular PathwaysMolecular Biology Techniques and Applications