Solvent- and additive-free oxidative amidation of aldehydes using a recyclable oxoammonium salt
Arturo León Sandoval, Katrina E. Doherty, Geoffrey P. Wadey, Nicholas E. Leadbeater
Abstract
A range of acyl azoles have been prepared from aromatic, heteroaromatic, and aliphatic aldehydes by means of an oxidative amidation reaction. The methodology employs a substoichiometric quantity of an oxoammonium salt as the oxidant. It avoids the need for additives such as a base, is run solvent-free, and the oxoammonium salt is recyclable.
Topics & Concepts
ChemistrySalt (chemistry)Oxidative phosphorylationSolventOrganic chemistryBase (topology)Reaction conditionsFree baseCombinatorial chemistryCatalysisBiochemistryMathematical analysisMathematicsChemical Synthesis and AnalysisOxidative Organic Chemistry ReactionsSynthesis and Catalytic Reactions