Nickel-Catalyzed Decarbonylative Reductive Alkylation of Aroyl Fluorides with Alkyl Bromides
Qiang Chen, Jingwen You, Tian Tian, Zhenyao Li, Myuto Kashihara, Hiroki Mori, Yasushi Nishihara
Abstract
This paper describes the nickel-catalyzed reductive alkylation of aroyl fluorides with alkyl bromides in a decarbonylative manner. In this reaction, various functional groups are well tolerated and the C(sp2)–C(sp3) bond can be constructed directly without the use of organometallic reagents. The present reaction is a cross-electrophile coupling via the radical pathway, affording the corresponding alkylarenes in moderate to good yields.
Topics & Concepts
ChemistryAlkylationAlkylReagentCatalysisElectrophileNickelReductive eliminationMedicinal chemistryCombinatorial chemistryOrganic chemistryCatalytic C–H Functionalization MethodsFluorine in Organic ChemistryRadical Photochemical Reactions