Synthesis, crystal structure and <i>in silico</i> studies of novel 2,4-dimethoxy-tetrahydropyrimido[4,5-<i>b</i>]quinolin-6(7<i>H</i>)-ones
Subham G. Patel, Ruturajsinh M. Vala, Paras J. Patel, Dipti B. Upadhyay, Venkatachalam Ramkumar, Ramesh L. Gardas, Hitendra M. Patel
Abstract
. Furthermore, 2,4-dimethoxy-THPQs with a 3-chloro substitution in the phenyl ring have the highest binding affinity because of the additional formation of halogen bonds and highest dipole moment.
Topics & Concepts
In silicoChemistryCrystal structureCrystallographyBiochemistryGeneMulticomponent Synthesis of HeterocyclesSynthesis and biological activitySynthesis and Characterization of Heterocyclic Compounds