Targeting RAS-RAF pathway significantly improves antitumor activity of Rigosertib-derived platinum(IV) complexes and overcomes cisplatin resistance
Zhikun Liu, Meng Wang, Heng‐Shan Wang, Lei Fang, Shaohua Gou
Topics & Concepts
CisplatinChemistryApoptosisSignal transductionCytotoxicityA549 cellKinaseIC50Cell growthIn vitroMAPK/ERK pathwayCell cycleCancer researchIntrinsic apoptosisCancer cellPharmacologyCaspaseBiochemistryCancerProgrammed cell deathBiologyMedicineInternal medicineChemotherapyMetal complexes synthesis and propertiesCancer Mechanisms and TherapyMelanoma and MAPK Pathways