Regio- and Stereoselective Alkylboration of Endocyclic Olefins Enabled by Nickel Catalysis
Chao Ding, Yaoyu Ren, Caocao Sun, Jiao Long, Guoyin Yin
Abstract
Whereas there is a significant interest in the rapid construction of diversely substituted saturated heterocycles, direct and modular access is currently limited to the mono-, 2,3-, or 3,4-substitution pattern. This Communication describes the straightforward and modular construction of 2,4-substituted saturated heterocycles from readily available materials in a highly stereo- and regioselective manner, which sets the stage for numerous readily accessible drug motifs. The strategy relies on chain walking catalysis.
Topics & Concepts
ChemistryRegioselectivityStereoselectivityModular designCatalysisCombinatorial chemistryNickelSubstitution (logic)StereochemistryOrganic chemistryProgramming languageComputer scienceCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisSynthetic Organic Chemistry Methods