Neighboring group-directed asymmetric [2 + 2 + 2] cycloaddition to access C–N axially chiral indoles
Xuan Zhang, Teng Qi, Yanru Ren, Baitong Wei, Chen‐Ho Tung, Zhenghu Xu
Abstract
A Rh-catalyzed neighboring group-directed asymmetric [2 + 2 + 2] cycloaddition of 1,6-diynes and ynamides to generate C–N axially chiral indole derivatives has been developed.
Topics & Concepts
Axial symmetryChemistryCycloadditionIndole testGroup (periodic table)StereochemistryEnantioselective synthesisCombinatorial chemistryCatalysisMedicinal chemistryOrganic chemistryMathematicsGeometryAxial and Atropisomeric Chirality SynthesisCatalytic Alkyne ReactionsCatalytic C–H Functionalization Methods