Selective induction of Rab9-dependent alternative mitophagy using a synthetic derivative of isoquinoline alleviates mitochondrial dysfunction and cognitive deficits in Alzheimer's disease models
Jee‐Hyun Um, Dong Jin Shin, Se Myeong Choi, Alen Benhur Pravin Nathan, Young Yeon Kim, Da Ye Lee, Dae Jin Jeong, Dong Hyun Kim, Kyung Hwa Kim, Young Hye Kim, Jihoon Nah, Jeong-Hee Jeong, Eunhee Yoo, Hwa Kyoung Shin, Hwan Tae Park, Ji Hoon Jo, Jong Hyun Cho, Jeanho Yun
Abstract
Our results highlight the therapeutic potential of ALT001 for AD via alleviation of mitochondrial dysfunction and indicate the usefulness of the ULK1-Rab9 alternative mitophagy pathway as a therapeutic target.
Topics & Concepts
MitophagyMitochondrionCell biologyBiologyAutophagyPharmacologyBiochemistryApoptosisAutophagy in Disease and TherapyAlzheimer's disease research and treatmentsCholinesterase and Neurodegenerative Diseases