Synthesis and biological evaluation of celastrol derivatives as potent antitumor agents with STAT3 inhibition
Shaohua Xu, Ruolan Fan, Lu Wang, Weishen He, Haixia Ge, Hailan Chen, Wen Xu, Jian Zhang, Wei Xu, Yaqian Feng, Zhimin Fan
Abstract
was verified on colorectal cancer organoid. This is the first research that discovered effective STAT3 inhibitors as potent anti-tumour agents from celastrol derivatives.
Topics & Concepts
CelastrolChemistrySTAT3ApoptosisCell cultureCancer researchPharmacologyBiochemistryBiologyGeneticsNatural Compounds in Disease TreatmentBioactive Compounds and Antitumor AgentsCytokine Signaling Pathways and Interactions