Physical exercise may exert its therapeutic influence on Alzheimer's disease through the reversal of mitochondrial dysfunction via SIRT1–FOXO1/3–PINK1–Parkin-mediated mitophagy
Na Zhao, Jie Xia, Bo Xu
2020Journal of sport and health science/Journal of Sport and Health Science69 citationsDOIOpen Access PDF
Abstract
• Physical exercise efficiently prevents the progression of Alzheimer's disease and mitigates the risk of developing the disease. • Physical exercise acts against the development and progression of Alzheimer's disease via promoting mitochondrial fitness. • Physical exercise may exert its therapeutic influence on Alzheimer's disease through the reversal of mitochondrial dysfunction via SIRT1-FOXO1/3-PINK1-Parkin–mediated mitophagy.
Topics & Concepts
ParkinPINK1MitophagyDiseaseMedicineNeuroscienceMitochondrionParkinson's diseasePhysical exerciseBioinformaticsBiologyInternal medicineAutophagyCell biologyGeneticsApoptosisAutophagy in Disease and TherapySirtuins and Resveratrol in MedicineTryptophan and brain disorders