From saliva to SNP: non-invasive, point-of-care genotyping for precision medicine applications using recombinase polymerase amplification and giant magnetoresistive nanosensors
Ana Sofia de Olazarra, Dana L. Cortade, Shan X. Wang
Abstract
PCR genotyping assay that was formerly validated using pyrosequencing. This automated, portable, and multiplexed RPA and GMR assay shows great promise as a solution for SNP genotyping at the POC and reinforces the broad applications of magnetic nanotechnology in biomedicine.
Topics & Concepts
GenotypingRecombinase Polymerase AmplificationSNP genotypingSNPLoop-mediated isothermal amplificationPoint of careNanosensorBiologyGeneticsMaterials scienceMedicineGenotypeNanotechnologySingle-nucleotide polymorphismDNAPathologyGeneBiosensors and Analytical DetectionAdvanced biosensing and bioanalysis techniquesMolecular Biology Techniques and Applications