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Elevated expression of Piezo1 activates the cGAS-STING pathway in chondrocytes by releasing mitochondrial DNA

Lin Sun, Yao Wang, Tianyou Kan, Han Wang, Junqi Cui, Wang Liao, Chenglei Liu, Hanjun Li, Zhifeng Yu, Mengning Yan

2025Osteoarthritis and Cartilage30 citationsDOI

Topics & Concepts

StingCell biologyMitochondrial DNAPIEZO1ChemistryBiologyGenePhysicsBiochemistryThermodynamicsMechanosensitive channelsReceptorIon channelinterferon and immune responsesOsteoarthritis Treatment and MechanismsHigh Altitude and Hypoxia
Elevated expression of Piezo1 activates the cGAS-STING pathway in chondrocytes by releasing mitochondrial DNA | Litcius