Platelets from HIV-infected individuals on antiretroviral drug therapy with poor CD4 <sup>+</sup> T cell recovery can harbor replication-competent HIV despite viral suppression
Fernando Real, Claude Capron, Alexis Sennepin, Riccardo Arrigucci, Aiwei Zhu, Gérémy Sannier, Jonathan Zheng, Lin Xu, Jean-Marc Massé, S. Greffe, Michelle Cazabat, Maribel Donoso, Pierre Delobel, Jacques Izopet, Eliseo A. Eugenín, Maria Laura Gennaro, É. Rouveix, Elisabeth Cramer Bordé, Morgane Bomsel
Abstract
In virally suppressed HIV-infected individuals on antiretroviral drug therapy, platelets harboring HIV correlate with poor immunological recovery.
Topics & Concepts
VirologyHuman immunodeficiency virus (HIV)DrugAntiretroviral therapyViral replicationDrug holidayLentivirusMedicineVirusPlateletViral loadImmunologyViral diseasePharmacologyHIV Research and TreatmentHIV-related health complications and treatmentsHIV/AIDS Research and Interventions