A J-aggregating cyanine-based NIR-II optical sensor for DNA aptamer-mediated detection and imaging of quinine
Gaowei Deng, Chaobang Zhang, Jiawei Chen, Fang Zeng, Shuizhu Wu
Abstract
We report a dye-displacement assay for quinine detection integrating a DNA aptamer with a J-aggregating NIR-II cyanine dye. This platform achieves sensitive, selective, and label-free NIR-II colorimetric and fluorescence sensing, with a fluorescence-based detection limit as low as 0.014 μM in urine solution, and enables NIR-II fluorescence imaging.
Topics & Concepts
CyanineAptamerDNAQuinineChemistryCombinatorial chemistryNanotechnologyMaterials scienceBiologyBiochemistryPhysicsMolecular biologyOpticsFluorescenceImmunologyMalariaAdvanced biosensing and bioanalysis techniquesMolecular Sensors and Ion DetectionAnalytical Chemistry and Chromatography