The role of ankyrin repeat-containing proteins in epigenetic and transcriptional regulation
Meijuan Wu, Yulu Zhao, Jiahe Yang, Fangyuan Yang, Yan Dai, Qian Wang, Cheng Chen, Xiaoyuan Chu
Abstract
Ankyrin repeat (AR) motif is one of the most abundant repeat motifs found in eukaryotic proteins. It functions in mediating protein-protein interactions and regulating numerous biological functions. Interestingly, some AR-containing proteins are involved in epigenetic and transcriptional events. Our review aims to characterize the structure and post-translational modification of AR, summarize the prominent role of AR-containing proteins in epigenetic and transcriptional events, emphasizing the crucial functions mediated by AR motifs.
Topics & Concepts
Ankyrin repeatEpigeneticsAnkyrinBiologyTranscriptional regulationCell biologyComputational biologyGeneticsTranscription factorGeneEpigenetics and DNA MethylationLipid metabolism and biosynthesisMicrotubule and mitosis dynamics