Prevalence of intratumoral regulatory T cells expressing neuropilin-1 is associated with poorer outcomes in patients with cancer
Christopher A Chuckran, Anthony R. Cillo, Jessica Moskovitz, Abigail E. Overacre-Delgoffe, Ashwin Somasundaram, Feng Shan, Grant Magnon, Sheryl Kunning, Irina Abécassis, Amer H. Zureikat, James D. Luketich, Arjun Pennathur, John Sembrat, Mauricio Rojas, Daniel T. Merrick, Sarah E. Taylor, Brian Orr, Francesmary Modugno, Ron Buckanovich, Robert E. Schoen, Seungwon Kim, Umamaheswar Duvvuri, Herbert J. Zeh, Robert P. Edwards, John M. Kirkwood, Lan Coffman, Robert L. Ferris, Tullia C. Bruno, Dario A.A. Vignali
Abstract
Persistent T cell receptor stimulation drives neuropilin-1 on intratumoral regulatory T cells, which is associated with poor clinical outcome.
Topics & Concepts
Neuropilin 1CancerMedicineInternal medicineCancer researchOncologyVEGF receptorsVascular endothelial growth factorCancer Immunotherapy and BiomarkersImmune Cell Function and InteractionT-cell and B-cell Immunology